A Swedish study is causing anxiety among many that mRNA vaccines can insert into our DNA. Here’s what’s REALLY going on.

Here’s the study. Here’s a good outline of reverse transcriptase and integrase. And here’s another piece on viral genome integration.
FREE CME when reflecting on this content for subscribed Supporters, check your supporter feed on LocalsFacebook or YouTube for the link along with an AD-FREE upload of the video 🙌
[Reflect on what you learned during this show and earn up to 1 AMA PRA Category 1 Credit ™ (applicable to physicians, nurse practitioners, PAs). For all other health professionals, please check with your state board as to whether they accept these AMA credits for CE requirements. Please note, credit is earned not from the content of the episode, but from your reflection on the content. Powered by CMEfy – a seamless way for busy clinician learners to discover Internet Point-of-Care Learning opportunities that reward CME credits & more. Learn more here.]
Transcript Below

The PayPal Tip Jar!

– [Zubin] Hey, so a lot of people have sent me this recent Swedish study that implies that Pfizer’s mRNA vaccine actually incorporates into our DNA and might scramble our genes. At least that’s how it’s been framed by a lot of vaccine-hesitant folks. And the people who email me are actually legitimately concerned. They’re worried, they’re like, oh my gosh, this implies that this vaccine that I have either taken or I’m planning to take is gonna actually harm my genetics. And maybe what if it crosses the placenta and harms the genetics of a child and pregnant moms and all that.

Okay, I looked at this paper very carefully, and I’m gonna tell you right now there is nothing to worry about, but let’s go through it so that you can understand, all right? And it’s difficult to understand this. I have a degree with honors in Molecular and Cell Biology from UC Berkeley. I had to read this thing very carefully, still. All right? So a layperson has no hope of this without help. So this is the background of this that you need to understand before we can look at the paper. And by the way, it was published in the current issues in Molecular Biology, which is a kind of a lower grade journal, not cited very often.

You have to pay to kinda publish in it. So you always wanna look at those things first off. The first things you need to understand is how the vaccine kind of works. So we have DNA, which is our genetic code that lives in our nucleus. That DNA is to make proteins is transcribed. It’s like an instruction set. It’s transcribed into messenger RNA that messenger RNA leaves the nucleus, goes into the cytoplasm of the cell where these ribosomes, which are little cellular machines, turn it into, it’s like an email instruction code, turns it into a protein, and those proteins then kind of self-assemble into different structures that we need for life.

The way viruses work, SARS-CoV-2 is it’s an RNA virus, and it comes and it injects its RNA that has the instructions, kind of like a messenger RNA, to make itself. So it hijacks the ribosomes and makes copies of itself that self-assemble and get pushed out through the membranes, and that’s how you get viruses. So what the Pfizer vaccine does, and the Moderna, for that matter, is they take messenger RNA, and they’ve designed their own sort of altered messenger RNA that codes for the spike protein only. So not the other parts of the virus that will cause it to assemble and cause harm, but just the spike protein.

They then wrap it in a lipid nanoparticle so it isn’t broken down, because messenger RNA is very unstable. It breaks down very quickly. And that lipid nanoparticle then can fuse with cell membranes, which are also sort of phospholipids, and allow that little email to enter the cell where it’s then transcribed by the ribosomes into protein. That spike protein, this protein goes to the cell surface, tells the immune system, hey, look here, this is not something you want. Learn how to fight it so when the real virus comes you don’t get severely ill. All right, you get a headstart on it, a little memory boost for it.

That’s the principle of how these things work. Now from the early days of the vaccine people were expressing concern, well could this messenger RNA be put into our own DNA and alter our own genome? Which could, it could cause cancers, it could cause mutations, it could cause problems, because other viruses can do this. In fact, retroviruses actually, like HIV, are actually designed to do this. They have RNA, they inject it into the cell. That RNA cannot turn into DNA unless it gets into the nucleus and actually is turned into DNA and then is integrated into our own DNA. Well, to do that, you need two things. You need an enzyme called reverse transcriptase, which the virus has, it actually it codes for, and that reverse transcriptase turns RNA back into DNA, hence the term reverse. So normally you’re turning DNA into messenger RNA. This does the opposite. So now you have DNA.

Then what the virus does is it has an enzyme called integrase. Integrates then allows that DNA to incorporate into our DNA. And once it’s there, it can be transcribed into mRNA and make copies of virus. So there’s a long history of these viruses actually incorporating into our DNA. And actually there are probably large segments of our own DNA that contain old viral pieces and these kinda transposons and different things like that. It gets beyond the scope of this discussion. So there’s precedent for that. So what, so people were concerned, could mRNA then get into our DNA? Now, here’s what’s missing in the Pfizer vaccine, reverse transcriptase and integrase. So those steps are missing. Now, what this study did that was it said, well, wait, humans have a form of reverse transcriptase that’s native to humans that does very specific things in the cell. What if that could turn the RNA from the Pfizer vaccine into DNA and then incorporate into the genome theoretically? Well, so what they did, was they then said, well let’s see if we can prove this. Now, you can tell by the way they’ve written the article that they already assume this is gonna happen, like they have a bias going in, and the kind of grammar’s a little funky and all that. Maybe it’s ’cause they’re Swedish, but you kinda wonder, did they even get this thing edited?

Again, it speaks to the quality of the journal. But what they did was they took cell lines in vitro. So this is not humans. It’s not in animals. It’s in vitro in a test tube, in a dish, in a Petri dish. These cell lines are called HUH7, HUH7 cells. They are carcinoma cells. They are liver cancer cells. So already they’re abnormal. They already replicate without any brakes on their replication. And they have totally sort of different activities on many levels, because they’re cancer cells. All right, so what they did was they took these cells and they bathed them in different concentrations of the Pfizer mRNA vaccine. Then, surprise, surprise, they saw that the mRNA entered the cells and was turned into spike protein. Okay, that’s perfect. That’s what they are designed to do. Now, typically we don’t bathe our liver cells in that mRNA construct, because it’s injected in the deltoid.

And so the concentrations that they reached around these cells would never be reached in real humans. So that’s one thing. And these are cancer cells. That’s another thing. And it’s not in the real human system. It’s in a Petri dish where they’re directly puttin’ this stuff on. That’s another thing. So about 1% of all in vitro studies actually show any clinical relevance in actual humans when you actually play them out. So that’s why in vitro is a start, but it’s not something that you panic over. I mean, there are a lotta things in vitro that stops SARS-CoV-2, but they don’t work in real humans. All right, so, or even in animals. What they then saw was, oh, let’s then grind up the cells, grind up the nuclei, dissolve all the RNA there using something called RNase, an enzyme. And whatever’s left is presumably DNA. And let’s run a PCR to see if we can detect spike protein DNA that would’ve been converted from the RNA by human reverse transcriptase. And lo and behold, they found DNA amplicons. They found DNA copies that they said were pretty much looked like they’d been transcribed from…

And again, I haven’t looked at the, I haven’t replicated the study. So I don’t know if they’re methods were flawed or if they, there’s something else wrong there, like other scientists have to replicate it, but I don’t even think it’s worth doing, but those are the caveats. What they found was, well, there’s DNA there, presumably in the nucleus. So this mRNA at these high concentrations they administered was converted by these cancer cells. Their own, presumably their own human reverse transcriptase into DNA. And that’s what the paper showed. So what does that mean? Well, without integrase, they even say in the paper, we do not see or have looked for evidence of integration into the genome, but they speculate, well maybe it can cross the placenta, and maybe it can and do this. But that means nothing. They never looked for actual integration into your DNA.

So the thing that people are saying is happening is not happening. That’s the simplest way to talk about it. Now here’s the best part. Since we don’t have integrase, we can’t do this. People forget there are two vaccines that we use that use DNA instead of mRNA. AstraZeneca and Johnson and Johnson. They use a DNA in an adenovirus, a replication deficient human or chimpanzee adenovirus, depending on the vaccine, that then injects this DNA, the DNA then does enter the nucleus. It is then transcribed into mRNA, that then makes spike protein. So we already have vaccines that actually put spike protein DNA in the nucleus. And those don’t integrate into our DNA. We haven’t seen massive examples of cancers and infertility and all the things anti-vaxxers say that are happening, which we don’t see on the ground at all. And so we already do this. So nothing in this paper is like, huh? If it’s even true, because you’re using cancer cells in vitro. So the bottom line is, should you worry about scrambling your DNA with an mRNA vaccine? Answer is not based on anything we’ve seen or any evidence we have to date at all. All right? Now, there’s always something that could show up later, but mm, it’d be pretty farfetched based on all the things I’ve said. So all of that being said… Now, what happens, what would happen if spike protein actually did incorporate into DNA? Well, we’re not even sure it would be harmful, right? Because the spike protein itself, contrary to what, there’s a lot of anti-vaccine rhetoric around spike protein. It’s actually just a protein.

It actually generates an immune response. It’s a foreign protein, but it in itself is not gonna cause widespread havoc. So the big picture is, don’t worry about this. And I know there are a lot of people who are stressed, so don’t. So share this video with people who are stressed about it. If you like, what we do in our style of educating hit us up, become a supporter of the show. That’s how we fund all this zdoggmd.com/supporters. Or you can make a one time donation to our PayPal, and I send an email to everybody who does that as a thank you. You can leave comments there and stuff. Don’t ask me medical questions, ’cause I really can’t answer those legally or ethically. That’s paypal.me/zdoggmd. I love you guys so much. And we are out, peace.

Related Videos